Physician/Author on Facebook. I'm not saying that there Is no link between Synthroid and lung cancer. I can understand why tennis 123 wrote, "I have so much to say about this I could write a book". CRF encompasses physical, emotional, and/or cognitive tiredness; is related to cancer or cancer treatments; and interferes with multiple dimensions of health-related quality of life (1-3).CRF is poorly understood, underrecognized, and undertreated. All the more reason to prescribe T3, I say! It does not necessarily imply one thing caused the other. (February 2002). This discussion has been closed to comments. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Iodine - and the lack of it - is implicated in breast cancer, after all. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. PLoSone 2011, 11:e27547. Once I got on the medication, the symptoms disappeared. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. PLoSone 2011, 11:e27547. You must log in or register to reply here. I cried with joy when I found out there was something really wrong with me. Monaldi Arch Chest Dis 2003, 59:140145. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. They only reappear when I need to fine tune the medication. It does not seem to quantify the increased risk, and it keeps saying it is hyperthyroidism that causes the oxidised stress. However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? If the results show that TSH is high and T-4 is low, then the diagnosis . Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). I have sent the link that I read today. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. Acta Endocrinol 1988, 118:460464. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. 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What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. She wrote about a product called Thyrtophin PMG. Join the Patient & Caregiver Network. Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Due to excessive bot signups along with nefarious actors we are limiting forum registration. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. hyperthyroidism. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. Nah, I would give this much credence. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Symptoms. The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Why not simply call it selenium deficiency? [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. bear in the big blue house characters; colne times obituaries this week Menu Toggle. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' The Remarkable Heart-Friendy Properties of Avocados. Correlation is NOT causation. Hypothyroidism can also lead to swelling of the tongue, hoarse voice, and sleep apnea. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. J. Clin. I invite those interested to read it and perhaps we can have a discussion on this study. Maybe because they "treat" only with T4 and not T3? I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. undefined will no longer be visible to you including posts, replies, and photos. Yes, lung cancer patients can have these symptoms, but so do patients who have other cancers. So I will leave it as a simple thank you for passing this along. I have so much to say about this I could write a book. I have always found this condition a riddle. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Forgot account? Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Oops, I just saw that I posted the same article. Could be another marmalade how would we know? 1). Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. But that's just me. But what can be done for patients who are at low radioactive treatments. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. The relationship between levothyroxine use and cancer risk is largely underdetermined. Is that what releases free radicals? 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. It looks at correlations, as if they had any merit on their own. For a better experience, please enable JavaScript in your browser before proceeding. View the data on GreenMedInfos Hypothyroidism Research page. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. Even in the mildest form, hypothyroidism affects the heart. Non-ASPS articles which could be relevant. Endocrinology 2008, 149:22412250. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. The very concept of "marketing" is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a 'TSH suppressor.' PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. Is Drug-Based Medicine a Form of Human Sacrifice? [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. I think part of sharing information here on Inspire is the discussions about the articles we share. Log In. Thus, I am monitored carefully. millions treated for hypothyroidism at risk for lung cancer. I have posted the link now. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. elevated TSH, without actually improving the overall physiological situation, nor the patients subjective experience of well being. Dr Childs guesses that patients on levothyroxine monotherapy may be more prone to cancer because they might be under-treated. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Endocrinology 1985, 117:12011208. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. Oops I have just bought my first jar of marmalade in over ten years! I wonder if only t3 treatments are preferable than t4 and t3 ? Join the forum, it's quick and easy . Data sources: The Medline and Cochrane Library electronic databases . El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. Endocrinol. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Nope. I posted it to see what anyone had to add. Diagnosed 1/12 with lung cancer out of the blue. I am just as much in the dark as some others on this site. 500+ pages of Natural Medicine Alternatives and Information. SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)", International Journal of Human Nutrition and Functional Medicine, Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency, 6 Bodily Tissues That Can Be Regenerated Through Nutrition, 7 Simple Ways to Unclog Your Arteries Naturally, Herbal Cream Clears 87.7% of HPV Cases Naturally, How WHOLE Turmeric Heals the Damaged Brain. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? Whether it should be treated remains controversial. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Untreated hypothyroidism increases morbidity and mortality. Other factors that can trigger thyroid problems include: autoimmune diseases like Hashimoto's or Graves' disease; thyroid surgery; radiation treatments to the neck or upper chest; and certain medications, including interferon alpha and interleukin-2 cancer medications, amiodarone . El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. I have been reading Izabella Wentz. Endocrinology 1985, 117:12011208. http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. It may not display this or other websites correctly. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. Angiology 2000, 51:S65S68. I don't think so. Thanks, I am not suggesting I believe in all that I see. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Just another excuse for keeping us on doses that are too low. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. Also this study finds no link with breast cancer, when others have found a link. The study included more than 128,000 veterans aged 18 to 26 and found that, just 30.2% of females and 18.7% of males had received HPV vaccination. Baked or Fried avocado fries [Vegetarian]. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor.